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KMID : 0371319840260040426
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Journal of the Korean Surgical Society
1984 Volume.26 No. 4 p.426 ~ p.432
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An Evaluation of Estrogen Receptors in Primary Breast Cancer
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金永福/Kim, Young Bog
金善京/鄭聖光/金學潤/Kim, Sun Kyung/Chung, Sung Kwang/Kim, Hak Yoon
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Abstract
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The estrogen receptor system is only part of a complex hormonal mechanism which influences breast cancer growth and function.
Estrogen receptor assay was performed- by Dextran-coated Charcoal Assay in the breast cancer tissue of 35 breast cancer patients who had been treated at Surgical Department of the Chonnam National University Hospital from June 1981 to May 1983. The pathologic and prognostic correlates of estrogen receptor in primary breast cancer were evaluated in retrospective manner. Although the estrogen receptor assay is a highly useful tumor marker and guide for therapy of advanced breast cancer, its relationship to the prognostic variables of primary breast cancer is complex and controversial and merits study.
The results of this report are summarized as followings;
1) Twenty patients were ER positive(57.1%), 15 ER negative, and a total of 35 who had curative resections were all available for follow-up(mean follow-up time 13 months).
2) Of the premenopausal patients, 42.9% were ER positive, and of the postmenopausal patients 56.7% ER positive.
3) Recurrence rate was 33.3% in the positive patients for 13 months(mean), and 66. 7% in the ER negative patients for 12.5 months(mean)
4) Disease-free interval was 12 months in ER positive patients, and 11 months in ER negative patients
5) There was higher ER positivity(75%) in histologic grade IQ than in grade 1 , and 11.
6) There was no significant correlation of the ER status to the clinical stage, the axillary lymph node metastasis level, and the histologic type of the breast cancer.
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KEYWORD
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